The 3 cc Oasis HLB cartridges contain the Oasis HLB sorbent, which is a universal polymeric reversed-phase sorbent that was developed for the extraction of a wide range of acidic, basic, and neutral compounds from various matrices using a simple, generic protocol. Since the Oasis HLB sorbent is water wettable, it maintains its capability for higher retention and excellent recoveries even if the sorbent runs dry, which means there is no need to take extraordinary steps to keep the sorbent beds from drying out during the critical steps prior to sample loading. These syringe-barrel-type cartridges are designed for use with vacuum manifolds and automated SPE instruments.